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Combo-pilling could be the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure and heartbeat, and shouldn't be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must 't be used in patients with uncontrolled high blood pressure, in addition to by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. --Participating in support groups that help the family with the addict recover (like Al-Anon or Nar-Anon).